MRTFB: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

MRTFB

Synonyms

MKL2 | MRTF-B | NPD001

Gene Description

MRTFB, myocardin related transcription factor B, is a transcriptional cofactor that associates with Serum Response Factor (SRF) to synergistically activate transcription of target genes (PMID: 12397177), plays a role in cell cycle progression (PMID: 23656782), and is essential for skeletal muscle development (PMID: 27385017), smooth muscle differentiation, and cardiovascular development (PMID: 15951419). A fusion with RREB1 and MRTFB has been identified in ectomesenchymal chondromyxoid tumour (PMID: 31991003).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
57496	16	16p13.12	NM_001308142	Unknown

Additional content available in

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Gene Variants 2
Category Variants 1
Molecular Profiles 1
Evidence 0
Clinical Trials 0

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MRTFB - Gene Detail

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