PTK7: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

PTK7

Synonyms

CCK-4 | CCK4

Gene Description

PTK7, protein tyrosine kinase 7 (inactive), is a catalytically-inactive receptor protein tyrosine kinase that is involved in non-canonical Wnt signaling and plays a role in cell migration (PMID: 27438854, PMID: 27499181). Dysregulation of Ptk7 expression has been demonstrated in various tumor types, including colorectal cancer and ovarian cancer (PMID: 27499181, PMID: 25550828) and decreased expression has been reported in invasive ductal breast cancer (PMID: 31933919), while overexpression has been observed in hepatocellular carcinoma (PMID: 31730575) and cervical cancer (PMID: 30944666).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
5754	6	6p21.1	NM_002821	Unknown

Additional content available in

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Gene Variants 7
Category Variants 1
Molecular Profiles 7
Evidence 13
Clinical Trials 2

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PTK7 - Gene Detail

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