PTPRO - Gene Detail
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| Gene Symbol | PTPRO | ||||||||||||
| Synonyms | GLEPP1 | NPHS6 | PTP-OC | PTP-U2 | PTPROT | PTPU2 | R-PTP-O | ||||||||||||
| Gene Description | PTPRO, protein tyrosine phosphatase receptor type O, is an R3-type receptor-like protein tyrosine phosphatase, which has tumor suppressor activity (PMID: 34880876) and regulates signaling pathways involved in fatty acid metabolism (PMID: 35904817), cell proliferation (PMID: 34719307, PMID: 16888096), migration, invasion, and apoptosis (PMID: 38182570), and plays a role in regulating immune cell growth, activation, and response (PMID: 34880876). Decreased expression of Ptpro has been observed in lung adenocarcinoma (PMID: 38182570) and hypermethylation has been identified in lung squamous cell carcinoma (SCC) (PMID: 28586036), esophageal SCC (PMID: 22099875), breast cancer (PMID: 24919593), and chronic lymphocytic leukemia (PMID: 17545520). | ||||||||||||
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