PTPRR: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

PTPRR

Synonyms

EC-PTP | PCPTP1 | PTP-SL | PTPBR7 | PTPRQ

Gene Description

PTPRR, protein tyrosine phosphatase receptor type R, is a member of the protein tyrosine phosphatases family and may negatively regulate MAPK/ERK1/2 pathway signaling (PMID: 31024255). An ETV6-PTPRR fusion has been identified in acute myelogenous leukemia (PMID: 16061641) and overexpression of Ptprr has been associated with poor prognosis in prostate cancer (PMID: 32133801), while Ptprr has been shown to have decreased expression in other tumor types, including colorectal carcinoma, cervical cancer, oral squamous cell carcinoma (PMID: 32133801), and ovarian cancer (PMID: 31653698).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
5801	12	12q15	NM_002849	Unknown

Additional content available in

CKB BOOST

Gene Variants 3
Category Variants 0
Molecular Profiles 2
Evidence 0
Clinical Trials 0

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PTPRR - Gene Detail

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