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Gene Symbol KMT2C
Synonyms HALR | KLEFS2 | MLL3
Gene Description KMT2C, lysine methyltransferase 2C, is a H3K4 histone methyltransferase (PMID: 31128216) that is involved in transcriptional coactivation and functions in chromatin modification (PMID: 31337554) and epigenetic gene regulation (PMID: 31128216). KMT2C mutations are associated with various tumor types (PMID: 24965397; PMID: 23429989; PMID: 24670651), including breast cancer (PMID: 31128216), diffuse-type gastric adenocarcinoma (PMID: 30108106), and urothelial carcinoma (PMID: 30665945).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
58508 7 7q36.1 NM_170606 Tumor suppressor (PMID: 30606230)
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