RAC1: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

RAC1

Synonyms

MIG5 | MRD48 | p21-Rac1 | Rac-1 | TC-25

Gene Description

RAC1, Rac family small GTPase 1, is a member of the Rho-family small GTPases that is involved in diverse cellular activities through regulating actin dynamics (PMID: 14744429) and functions in cell proliferation, cell survival, epithelial mesenchymal transition, and cell motility (PMID: 32178475). RAC1 mutations have been identified in human cancers including melanoma, head and neck cancer, and prostate cancer (PMID: 27991930), and Rac1 may play a role in in resistance to chemotherapy in breast cancer (PMID: 32193458).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
5879	7	7p22.1	NM_006908	Oncogene (PMID: 30606230)

Additional content available in

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Gene Variants 30
Category Variants 3
Molecular Profiles 32
Evidence 7
Clinical Trials 0

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RAC1 - Gene Detail

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