We’re improving your experience!

Starting April 21, you’ll be asked to log in or sign up for a free account after viewing 10 content pages each month.

Don’t worry—creating an account is quick and easy, and it comes with added benefits! Once logged in, you’ll not only continue accessing the content you already enjoy, but you’ll also unlock exclusive features like interactive donut plots for variant protein effects and variant impacts across the gene.

Stay tuned for these updates, and thank you for being part of our community!

RAC2 - Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol RAC2
Synonyms EN-7 | Gx | HSPC022 | IMD73A | IMD73B | IMD73C | p21-Rac2
Gene Description RAC2, Rac family small GTPase 2, encodes a hematopoietic-specific GTPase that regulates phagocyte NADPH oxidase activity (PMID: 11224519, PMID: 11145705), and plays a role in various immune cell processes, including neutrophil migration (PMID: 10072071, PMID: 10961859, PMID: 14564009), survival and maintenance of B-lymphocytes (PMID: 14564011), and actin polymerization in T-lymphocytes (PMID: 11581314). RAC2 mutations have been identified in melanoma (PMID: 22817889) and increased expression of Rac2 has been identified in clear cell renal cell carcinoma (PMID: 31364727).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
5880 22 22q13.1 NM_002872 Unknown
Additional content available in Icon for CKB-BoostCKB BOOST