Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol RAD51C
Synonyms BROVCA3 | FANCO | R51H3 | RAD51L2
Gene Description RAD51C, RAD51 paralog C, functions in homologous recombination in DNA repair and plays a role in cell cycle checkpoint signaling in response to DNA damage (PMID: 21821141). Germline mutations in RAD51C are associated with increased susceptibility to breast and ovarian cancers (PMID: 21821141, PMID: 31446535) and overexpression of Rad51c has been observed in ovarian cancer (PMID: 32055267).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
RAD51C A126T no effect
RAD51C A155E loss of function Olaparib
RAD51C A155V unknown
RAD51C A279D unknown
RAD51C A279P loss of function Olaparib
RAD51C A279V unknown
RAD51C A308S unknown
RAD51C A308T unknown
RAD51C A30E no effect - predicted
RAD51C A324T unknown
RAD51C amp no effect
RAD51C C135R loss of function Olaparib
RAD51C C135Y loss of function Olaparib
RAD51C D108G loss of function Olaparib
RAD51C D108Y no effect - predicted
RAD51C D141G unknown
RAD51C D159A loss of function Olaparib
RAD51C D159N unknown
RAD51C D159Y loss of function Olaparib
RAD51C D242N loss of function
RAD51C D318E unknown
RAD51C D348V loss of function - predicted Olaparib
RAD51C del loss of function Olaparib
RAD51C E146* loss of function - predicted Olaparib
RAD51C E360Q unknown
RAD51C E45D unknown
RAD51C E59K unknown
RAD51C E80* loss of function Olaparib
RAD51C E92K unknown
RAD51C F103V loss of function Olaparib
RAD51C G112V unknown
RAD51C G113S unknown
RAD51C G114R loss of function
RAD51C G114V loss of function Olaparib
RAD51C G125S unknown
RAD51C G125V loss of function Olaparib
RAD51C G130A loss of function Olaparib
RAD51C G130R loss of function
RAD51C G150E loss of function Olaparib
RAD51C G153D unknown Olaparib
RAD51C G153S unknown
RAD51C G162E unknown
RAD51C G162Efs*9 loss of function - predicted Olaparib
RAD51C G162R unknown
RAD51C G264S unknown
RAD51C G264V no effect
RAD51C G302V loss of function - predicted Olaparib
RAD51C G306R unknown
RAD51C G3R no effect
RAD51C H192_R193delinsGG no effect
RAD51C H192_R193delinsGG RAD51C R193* RAD51C R193L RAD51C R193W
RAD51C H250Y unknown
RAD51C I144T unknown
RAD51C inact mut loss of function Olaparib
RAD51C K131I loss of function Olaparib
RAD51C K26M unknown
RAD51C K320M unknown
RAD51C L138F unknown Olaparib
RAD51C L219S unknown Olaparib
RAD51C L226P loss of function Olaparib
RAD51C L257V unknown
RAD51C L262V unknown
RAD51C L265* loss of function - predicted Olaparib
RAD51C L27P loss of function - predicted Olaparib
RAD51C L357S unknown
RAD51C L91F no effect - predicted
RAD51C loss loss of function Olaparib
RAD51C M118I unknown
RAD51C M136L unknown
RAD51C M1? unknown
RAD51C mutant unknown
RAD51C N71D unknown
RAD51C over exp no effect
RAD51C P21A no effect
RAD51C P21S no effect - predicted
RAD51C P21T unknown
RAD51C P247L unknown
RAD51C P330H unknown
RAD51C P43S no effect - predicted
RAD51C Q11R no effect
RAD51C Q133E loss of function - predicted Olaparib
RAD51C Q133K loss of function Olaparib
RAD51C Q143R loss of function Olaparib
RAD51C R12W loss of function - predicted Olaparib
RAD51C R168G loss of function
RAD51C R193* loss of function Olaparib
RAD51C R193L no effect
RAD51C R193Q unknown
RAD51C R193W no effect
RAD51C R212C unknown
RAD51C R214C unknown Olaparib
RAD51C R237* unknown
RAD51C R237P loss of function Olaparib
RAD51C R249C no effect - predicted
RAD51C R249H unknown
RAD51C R258H loss of function Olaparib
RAD51C R260W unknown
RAD51C R312W loss of function Olaparib
RAD51C R319Q unknown
RAD51C R366Q loss of function - predicted Olaparib
RAD51C S105* loss of function - predicted Olaparib
RAD51C S163R loss of function Olaparib
RAD51C T102I loss of function Olaparib
RAD51C T121R loss of function Olaparib
RAD51C T132I loss of function
RAD51C T132P loss of function Olaparib
RAD51C T132R loss of function Olaparib
RAD51C T287A unknown Olaparib
RAD51C T336P unknown
RAD51C T5R unknown
RAD51C V140E loss of function Olaparib
RAD51C V140G loss of function Olaparib
RAD51C V156D loss of function Olaparib
RAD51C V169A no effect
RAD51C V350I unknown
RAD51C Y224H no effect - predicted