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Gene Symbol | RAD51B | ||||||||||
Synonyms | R51H2 | RAD51L1 | REC2 | ||||||||||
Gene Description | RAD51B, RAD51 paralog B, plays a role in homologous recombination repair of double-strand DNA breaks (PMID: 21821141, PMID: 32098697). RAD51B mutations are associated with susceptibility to breast cancer (PMID: 24139550, PMID: 29255180) and overexpression has been correlated with a favorable prognosis in non-small cell lung cancer (PMID: 29207658) and a poor prognosis in gastric cancer (PMID: 27651161). | ||||||||||
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Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
RAD51B amp | no effect | |
RAD51B del | loss of function | Olaparib |
RAD51B fusion | unknown | |
RAD51B inact mut | loss of function | Olaparib |
RAD51B L103* | loss of function - predicted | Olaparib |
RAD51B loss | loss of function | Olaparib |
RAD51B mutant | unknown | |
RAD51B over exp | no effect | |
RAD51B Q371* | unknown | |
RAD51B R8* | loss of function - predicted | Olaparib |
RAD51B rearrange | unknown | |
RAD51B V207L | unknown | |
RAD51B wild-type | no effect | |
RAD51B Y46* | loss of function - predicted | Olaparib |