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RET - Gene Detail

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Gene Symbol RET
Synonyms CDHF12 | CDHR16 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1
Gene Description RET, ret proto-oncogene, is a receptor tyrosine kinase that activates MAPK and PI3K/AKT pathways and regulates cell growth and differentiation (PMID: 24561444, PMID: 29134959, PMID: 32094155). RET germline mutations result in MEN2 syndromes and familial medullary thyroid carcinoma (PMID: 20930041, PMID: 24561444) and somatic RET activating mutations, fusions, and Ret amplification and/or overexpression has been associated with a variety of cancers including lung (PMID: 30257958) and colorectal (PMID: 30210625, PMID: 30038711).
ACMG Incidental List v3.0:
Yes, Multiple endocrine neoplasia type 2A (PMID: 34012068)
Yes, Familial medullary thyroid cancer (PMID: 34012068)
Yes, Multiple endocrine neoplasia type 2B (PMID: 34012068)
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
5979 10 10q11.21 NM_020975 Oncogene (PMID: 30606230)

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Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Molecular Profile Protein Effect Treatment Approaches
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries