Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol RFC4
Synonyms A1 | RFC37
Gene Description RFC4, replication factor C subunit 4, encodes the 37-kDa subunit of the replication factor C complex, which loads PCNA onto DNA (PMID: 9488738, PMID: 34751190), and is involved in DNA replication (PMID: 10656791, PMID: 10656792), maintenance of genomic stability (PMID: 33339954), and checkpoint control (PMID: 11438670). RFC4 overexpression has been demonstrated in hepatocellular carcinoma (PMID: 34053971), colorectal cancer (PMID: 25407051), cervical cancer (PMID: 17243165), and HPV-positive head and neck squamous cell carcinoma (PMID: 16467079).
Additional content available in CKB BOOST