RNF6: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

RNF6

Synonyms

Gene Description

RNF6, ring finger protein 6, is an E3 ubiquitin ligase that mediates ubiquitination and degradation of target proteins including AR (PMID: 19345326) and LIM kinase (PMID: 16204183), playing an important role in diverse signaling pathways (PMID: 35822825). Mutations in RNF6 have been identified in esophageal squamous cell carcinoma (PMID: 12154016) and increased expression of RNF6 has been identified in several tumor types (PMID: 35822825), including prostate cancer (PMID: 16204183), colorectal cancer (PMID: 29374067), and gastric cancer (PMID: 30323630).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
6049	13	13q12.13	NM_005977	Unknown

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Gene Variants 3
Category Variants 0
Molecular Profiles 3
Evidence 0
Clinical Trials 0

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RNF6 - Gene Detail

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