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Gene Symbol BCL9
Synonyms LGS
Gene Description BCL9, BCL9 transcription coactivator, is a nuclear transcriptional regulator that regulates the Wnt/beta-catenin (CTNNB1) signaling pathway (PMID: 29786110). Overexpression of BCL9 has been observed in adrenocortical carcinoma (PMID: 29428231), hepatocellular carcinoma (PMID: 28074862), and colon cancer (PMID: 30009824) and a MEF2D-BCL9 fusion has been identified in acute B-Cell precursor lymphoblastic leukemia (PMID: 27019113).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
607 1 1q21.2 NM_004326 Oncogene (PMID: 30606230)
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