Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene Symbol | RREB1 | ||||||||||
| Synonyms | FINB | HNT | LZ321 | RREB-1 | Zep-1 | ||||||||||
| Gene Description | RREB1, ras responsive element binding protein 1, is a zinc finger transcription factor, activated by the MAPK pathway, that regulates expression of several downstream targets, as a transcriptional repressor and transcriptional activator (PMID: 32210733), and may play a role in Ras signaling (PMID: 8816445, PMID: 24418439, PMID: 21703425). RREB1 overexpression has been demonstrated in colorectal cancer (PMID: 22751122), amplification of RREB1 has been reported in melanoma (PMID: 32210733), and a RREB1-TFE3 has been identified in myofibroblastic sarcoma (PMID: 21625565) and a RREB1-MRTFB fusion in ectomesenchymal chondromyxoid tumor (PMID: 31991003). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
