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Gene Symbol SDHD
Synonyms CBT1 | CII-4 | CWS3 | cybS | MC2DN3 | PGL | PGL1 | PPGL1 | QPs3 | SDH4
Gene Description SDHD, succinate dehydrogenase complex subunit D, is the small membrane-bound subunit of cytochrome b in mitochondrial complex II that catalyzes electron transfer from succinate to ubiquinone (PMID: 21771581). SDHD mutations are found in paragangliomas, extra-adrenal pheochromocytomas (PMID: 16317055, PMID: 15328326, PMID: 19454582, PMID: 31492822), and gastrointestinal stromal tumours (PMID: 29070651).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
6392 11 11q23.1 NM_003002 Tumor suppressor (PMID: 30606230)
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