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Gene Symbol SFPQ
Synonyms POMP100 | PPP1R140 | PSF
Gene Description SFPQ, splicing factor proline and glutamine rich, is a nuclear protein that interacts with RAD51 paralogs and plays a role in homologous recombination repair, and maintains sister chromatid cohesion (PMID: 20813759, PMID: 31204691). SFP1-TFE3 fusions are commonly associated with perivascular epithelioid cell tumors (PEComas) (PMID: 26274027), and a SFPQ-ABL1 fusion has been observed in B-cell precursor acute lymphoblastic leukemia (PMID: 32306475).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
6421 1 1p34.3 NM_005066 Tumor suppressor (PMID: 30606230)
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