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Gene Symbol BCL11B
Synonyms ATL1 | ATL1-alpha | ATL1-beta | ATL1-delta | ATL1-gamma | CTIP-2 | CTIP2 | hRIT1-alpha | IDDFSTA | IMD49 | RIT1 | SMARCM2 | ZNF856B
Gene Description BCL11B, BAF chromatin remodeling complex subunit BCL11B, encodes a component of the BAF chromatin remodeling complex (PMID: 23644491) that functions as a transcriptional repressor (PMID: 16091750, PMID: 20544728), thereby regulating the function and development of T cells (PMID: 25128552, PMID: 20969590) and the nervous system (PMID: 28424591). BCL11B mutations have been identified in T cell acute lymphoblastic leukemia (PMID: 21878675), and BCL11B fusions have been identified in a number of hematological malignancies including T-cell leukemia and acute myeloid leukemia (PMID: 15668700, PMID: 22867996, PMID: 24504345, PMID: 26186352).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
64919 14 14q32.2 NM_138576 Both: Oncogene and Tumor suppressor (PMID: 30606230)
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