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Gene Symbol SMARCA1
Synonyms hSNF2L | ISWI | NURF140 | SNF2L | SNF2L1 | SNF2LB | SNF2LT | SWI | SWI2
Gene Description SMARCA1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1, is a member of the ISWI subfamily of chromatin remodeling proteins that functions as an ATPase subunit for chromatin remodeling complexes and plays a role in regulation of gene expression (PMID: 28801535, PMID: 29249292) and cell proliferation (PMID: 22508985). Altered SMARCA1 expression and mutations in SMARCA1 have been identified in several tumor types, including mutations in uterine cancer (PMID: 36126083), lung cancer (PMID: 34298439), and gastric cancer (PMID: 25462860).
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