SMARCA4: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

SMARCA4

Synonyms

BAF190 | BAF190A | BRG1 | CSS4 | hSNF2b | MRD16 | OTSC12 | RTPS2 | SNF2 | SNF2-beta | SNF2L4 | SNF2LB | SWI2

Gene Description

SMARCA4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, is a member of the SWI/SNF family, which regulates transcription through chromatin remodeling (PMID: 27413115). Mutations in Smarca4 have been linked to rhabdoid tumors as well as breast, prostate, lung, pancreas, and colon cancers (PMID: 18437052, PMID: 24145903, PMID: 19234488).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
6597	19	19p13.2	NM_003072	Tumor suppressor (PMID: 30606230)

Additional content available in

CKB BOOST

Gene Variants 223
Category Variants 19
Molecular Profiles 230
Evidence 31
Clinical Trials 21

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Variant Tier Coding
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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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SMARCA4 - Gene Detail

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