SMARCE1: Gene Detail - Cancer Knowledgebase (CKB)

To all our CKB CORE users, don’t miss the latest new features now available! Register for a free CORE account here and then login for access. Feel free to contact us at ckbsupport@genomenon.com if you have any questions!

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol

SMARCE1

Synonyms

BAF57 | CSS5

Gene Description

SMARCE1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, encodes a core subunit of the SWI/SNF chromatin remodeling complex that is involved in cell cycle regulation and proliferation (PMID: 20460533), cellular senescence (PMID: 28716547), and induction of apoptosis (PMID: 16135788). Overexpression has been identified in breast cancer (PMID: 27495308) and prostate cancer metastases (PMID: 23493350), and SMARCE1 mutations have been identified in spinal meningiomas (PMID: 23377182).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
6605	17	17q21.2	NM_003079	Tumor suppressor (PMID: 30606230)

Additional content available in

CKB BOOST

Gene Variants 27
Category Variants 17
Molecular Profiles 27
Evidence 0
Clinical Trials 0

KEY FEATURES

CKB CORE^TM

CKB BOOST^TM

CKB FLEX^TM

Access 50 genes & related content

Access 2000+ genes & related content

Scalable & flexible content integration for 2000+ genes

Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

More about our plans

The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

SMARCE1 - Gene Detail

Contact