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Gene Symbol BRCA1
Synonyms BRCAI | BRCC1 | BROVCA1 | FANCS | IRIS | PNCA4 | PPP1R53 | PSCP | RNF53
Gene Description BRCA1, BRCA1 DNA repair associated, is a tumor suppressor (PMID: 30562755) involved in the DNA damage response and DNA repair (PMID: 21203981). BRCA1 germline mutations increase the risk of developing ovarian and/or breast cancer (PMID: 21285145) and somatic mutations are highest in NSCLC, pancreatic, and colon cancers (PMID: 27283171).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
672 17 17q21.31 NM_007294 Tumor suppressor (PMID: 30606230)
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