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Gene Symbol STAT5B
Synonyms GHISID2 | STAT5
Gene Description STAT5B, signal transducer and activator of transcription 5B, is a transcription factor of the JAK/STAT signaling pathway (PMID: 31690038) that regulates hematopoietic proliferation, differentiation, and apoptosis (PMID: 24416653). STAT5B activation is associated with prostate and hematological cancers (PMID: 24416653, PMID: 24573384, PMID: 18508994) and recurrent mutations have been identified in peripheral T cell leukemia/lymphoma (PMID: 31690038).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
6777 17 17q21.2 NM_012448 Both: Oncogene and Tumor suppressor (PMID: 30606230)
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