STAT5B: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

STAT5B

Synonyms

GHISID2 | STAT5

Gene Description

STAT5B, signal transducer and activator of transcription 5B, is a transcription factor of the JAK/STAT signaling pathway (PMID: 31690038) that regulates hematopoietic proliferation, differentiation, and apoptosis (PMID: 24416653). STAT5B activation is associated with prostate and hematological cancers (PMID: 24416653, PMID: 24573384, PMID: 18508994) and recurrent mutations have been identified in peripheral T cell leukemia/lymphoma (PMID: 31690038).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
6777	17	17q21.2	NM_012448	Both: Oncogene and Tumor suppressor (PMID: 30606230)

Additional content available in

CKB BOOST

Gene Variants 112
Category Variants 5
Molecular Profiles 112
Evidence 11
Clinical Trials 2

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Genes

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Gene Variants

Therapies

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Global Drug Approvals

Drug Classes

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Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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STAT5B - Gene Detail

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