ADAM17: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

ADAM17

Synonyms

Gene Description

ADAM17, ADAM metallopeptidase domain 17, is a member of the disintegrin and metalloprotease domain family, that functions in proteolytic processing of a number of membrane-bound substrates, including TNF-alpha and EGFR ligands, and plays a role in immunity, development, and inflammation (PMID: 31060243, PMID: 30992230). ADAM17 missense mutations have been observed in colon cancer (PMID: 31060243) and altered expression has been reported in lung cancer (PMID: 30833304).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
6868	2	2p25.1	NM_003183	Unknown

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Gene Variants 14
Category Variants 3
Molecular Profiles 14
Evidence 0
Clinical Trials 0

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ADAM17 - Gene Detail

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