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TAP1 - Gene Detail

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Gene Symbol TAP1
Synonyms ABC17 | ABCB2 | APT1 | D6S114E | MHC1D1 | PSF-1 | PSF1 | RING4 | TAP1*0102N | TAP1N
Gene Description TAP1, transporter 1, ATP binding cassette subfamily B member, forms a complex with TAP2 (PMID: 10581370), and functions as an ATP-dependent peptide transporter (PMID: 8348620) that interacts with MHC class I dimers (PMID: 7809108), playing a role in antigenic peptide transport, processing, and presentation (PMID: 12366777, PMID: 10618714). Loss of TAP1 has been identified in non-small cell lung cancer (PMID: 8546899) and overexpression of TAP1 has been identified in high grade breast carcinoma (PMID: 29091951).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
6890 6 6p21.32 NM_000593 Unknown
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