Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene Symbol | TEK | ||||||||||
| Synonyms | CD202B | GLC3E | TIE-2 | TIE2 | VMCM | VMCM1 | ||||||||||
| Gene Description | TEK (TIE2), TEK receptor tyrosine kinase, is the angiopoietin receptor tyrosine kinase that regulates angiogenesis and a variety of endothelial cell functions including proliferation, survival, and morphology (PMID: 28289658). Elevated TEK (TIE2) and Ang2 expression is negatively correlated with disease free survival and overall survival in patients with breast cancer (PMID: 28062977), decreased expression has been associated with poor prognosis in clear cell renal cell carcinoma (PMID: 30840266), and plasma levels may be a marker for response to VEGF inhibitors (PMID: 30405103). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
