TIAM1 - Gene Detail
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| Gene Symbol | TIAM1 | ||||||||||||
| Synonyms | NEDLDS | TIAM-1 | ||||||||||||
| Gene Description | TIAM1, TIAM Rac1 associated GEF 1, is a Rac-selective guanine nucleotide exchange factor (GEF) that functions downstream of Ras (PMID: 12134164), which regulates cytoskeleton organization and plays a role in cell migration (PMID: 23071154, PMID: 17825562), invasion (PMID: 20802514, PMID: 7999144), synaptic function (PMID: 37146610), and glucose homeostasis (PMID: 33923452). Mutations in TIAM1 have been identified in neuroblastoma (PMID: 28423360) and overexpression of Tiam1 has been observed in numerous tumor types (PMID: 24037532), including head and neck squamous cell carcinoma (PMID: 24189000), breast cancer (PMID: 27562113), and lung adenocarcinoma (PMID: 24661909). | ||||||||||||
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