TSC2 - Gene Detail
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| Gene Symbol | TSC2 | ||||||||||
| Synonyms | LAM | PPP1R160 | TSC4 | ||||||||||
| Gene Description | TSC2, TSC complex subunit 2, forms a complex with Tsc1 and inhibits mTOR pathway signaling, thus regulating cell growth and metabolism (PMID: 27226234). Germline TSC2 inactivating mutations cause tuberous sclerosis complex and somatic TSC2 mutations have been identified in various cancers, including renal cell carcinoma, sarcoma, and breast cancer (PMID: 27226234, PMID: 30303819, PMID: 28860410, PMID: 28027327). | ||||||||||
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