TWIST1: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

TWIST1

Synonyms

ACS3 | bHLHa38 | BPES2 | BPES3 | CRS | CRS1 | CSO | SCS | SWCOS | TWIST

Gene Description

TWIST1, twist family bHLH transcription factor 1, encodes a transcription factor that acts as an activator and repressor, regulating the expression of genes involved in several cellular processes, including embryogenesis (PMID: 21876555), epithelial-to-mesenchymal transition (PMID: 38139368), and apoptosis (PMID: 10485844, PMID: 26880587). Increased expression of Twist1 has been observed in several tumor types (PMID: 21876555), including hepatocellular carcinoma (PMID: 17000670), prostate cancer (PMID: 15958559), and esophageal squamous cell carcinoma (PMID: 16822877).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
7291	7	7p21.1	NM_000474	Unknown

Additional content available in

CKB BOOST

Gene Variants 5
Category Variants 1
Molecular Profiles 5
Evidence 0
Clinical Trials 0

KEY FEATURES

CKB CORE^TM

CKB BOOST^TM

CKB FLEX^TM

Access 50 genes & related content

Access 2000+ genes & related content

Scalable & flexible content integration for 2000+ genes

Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

More about our plans

The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

TWIST1 - Gene Detail

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