CCR2: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

CCR2

Synonyms

Gene Description

CCR2, C-C motif chemokine receptor 2, is a transmembrane receptor for the chemokines CCL2, CCL8, CCL7 and CCL13 (PMID: 23408426) and is also an alternative coreceptor for HIV-1 infection (PMID: 12192431). CCL2 expression from tumor cells facilitates metastasis by activating CCR2 in the endothelium, increasing vascular permeability (PMID: 22789541) and other studies have shown inhibition of Ccr2 prevents CCL2 induced cell invasion and viability (PMID: 28424406).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
729230	3	3p21.31	NM_001123041	Unknown

Additional content available in

CKB BOOST

Gene Variants 2
Category Variants 0
Molecular Profiles 2
Evidence 2
Clinical Trials 0

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(50 Genes)

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Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

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Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

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System Integration

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

CCR2 - Gene Detail

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