TYMS: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

TYMS

Synonyms

DKCD | HST422 | TMS | TS

Gene Description

TYMS, thymidylate synthetase, encodes an enzyme that catalyzes the conversion of deoxyuridine monophosphate and methylenetetrahydrofolate to thymidylate and dihydrofolate, which is an essential step in DNA biosynthesis (PMID: 8867733, PMID: 28634233), and acts as an RNA-binding protein, playing a role in the translational regulation of gene expression (PMID: 8867733, PMID: 12084459, PMID: 1924359). Increased expression of TYMS has been identified in lung cancer (PMID: 21321092) and breast cancer (PMID: 33030246), and has been associated with colorectal cancer (PMID: 31423175).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
7298	18	18p11.32	NM_001071	Unknown

Additional content available in

CKB BOOST

Gene Variants 1
Category Variants 0
Molecular Profiles 1
Evidence 0
Clinical Trials 0

KEY FEATURES

CKB CORE^TM

CKB BOOST^TM

CKB FLEX^TM

Access 50 genes & related content

Access 2000+ genes & related content

Scalable & flexible content integration for 2000+ genes

Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

More about our plans

The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

TYMS - Gene Detail

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