TYRO3 - Gene Detail

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Gene Symbol TYRO3
Synonyms BYK | Dtk | Etk-2 | Rek | RSE | Sky | Tif
Gene Description TYRO3, TYRO3 protein tyrosine kinase, is a member of the TAM family (Tyro3, Axl, and Mer) and plays a role in regulation of the immune system and cell survival, migration, and differentiation through activation of PI3K and AKT (PMID: 30322068, PMID: 20546121). Overexpression of Tyro3 has been observed in leukemia, thyroid cancer, metastatic colorectal cancer, and melanoma (PMID: 30322068), and is associated with metastasis and poor prognosis in gastric cancer (PMID: 32018224) and pancreatic cancer (PMID: 31765735).
NCBI Gene ID Chromosome Map Location Canonical Transcript MANE Select Gene Role
7301 15 15q15.1 NM_006293 Y Unknown

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Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Molecular Profile Protein Effect Treatment Approaches
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries