Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene Symbol | TYRO3 | ||||||||||
| Synonyms | BYK | Dtk | Etk-2 | Rek | RSE | Sky | Tif | ||||||||||
| Gene Description | TYRO3, TYRO3 protein tyrosine kinase, is a member of the TAM family (Tyro3, Axl, and Mer) and plays a role in regulation of the immune system and cell survival, migration, and differentiation through activation of PI3K and AKT (PMID: 30322068, PMID: 20546121). Overexpression of Tyro3 has been observed in leukemia, thyroid cancer, metastatic colorectal cancer, and melanoma (PMID: 30322068), and is associated with metastasis and poor prognosis in gastric cancer (PMID: 32018224) and pancreatic cancer (PMID: 31765735). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
