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Gene Symbol U2AF1
Synonyms FP793 | RN | RNU2AF1 | U2AF35 | U2AFBP
Gene Description U2AF1, U2 small nuclear RNA auxiliary factor 1, is a 35 kDa subunit splicing factor, that functions in 3' splice site recognition to regulate expression of genes involved in hematological and solid tumor development (PMID: 2963698, PMID: 28986033, PMID: 32303702). U2AF1 is frequently mutated in myelodysplatic syndrome (MDS), chronic myelomonocytic leukemia, atypical CML, acute myeloid leukemia, and lung adenocarcinoma (PMID: 23645565, PMID: 22678168, PMID: 24498085, PMID: 30138727, PMID: 29991672).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
7307 21 21q22.3 NM_006758 Oncogene (PMID: 30606230)
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