Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene Symbol | UBTF | ||||||||||
| Synonyms | CONDBA | NOR-90 | UBF | UBF-1 | UBF1 | UBF2 | ||||||||||
| Gene Description | UBTF, upstream binding transcription factor, is a transcription factor that activates ribosomal DNA transcription (PMID: 11756560, PMID: 16507361), regulates nucleolar organization (PMID: 24449107, PMID: 30656516), and is involved in genome stability (PMID: 25452314), viral replication (PMID: 25965800, PMID: 19399920), and neurodegeneration (PMID: 29300972, PMID: 28819135). UBTF is overexpressed in melanoma (PMID: 34663332), UBTF internal tandem duplications have been identified in pediatric acute myeloid leukemia (PMID: 33560403), and UBTF fusions have been identified in pheochromocytomas and paragangliomas (PMID: 33986121) and prostate cancer (PMID: 23814484). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
