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Gene Symbol KDM6A
Synonyms bA386N14.2 | KABUK2 | UTX
Gene Description KDM6A, lysine demethylase 6A, is a Jumonji domain histone demethylase that targets H3 lysine 27 (H3K27) to regulate gene transcription through chromatin remodeling and plays a role in cell growth and differentiation (PMID: 30753822). Altered expression of Kdm6a has been reported in HNSCC and bladder cancer (PMID: 25275298, PMID: 25225064) and mutations have been observed in acute myeloid leukemia, bladder carcinoma, breast cancer, chronic myeloid leukemia, colorectal adenocarcinoma, endometrial adenocarcinoma, clear cell renal cell carcinoma, and glioblastoma (PMID: 30753822).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
7403 X Xp11.3 NM_021140 Both: Oncogene and Tumor suppressor (PMID: 30606230)
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