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| Gene Symbol | VEGFC | ||||||||||
| Synonyms | Flt4-L | LMPH1D | LMPHM4 | VRP | ||||||||||
| Gene Description | VEGFC, vascular endothelial growth factor C, is a secreted ligand that binds to Kdr (Vegfr2), Flt4 (Vegfr3) and the neuropilin family receptors (PMID: 25888649), and plays a role in angiogenesis (PMID: 32132179) and may be a modulator of the immune system (PMID: 32154654). Elevated Vegfc expression has been associated with lymphangiogenesis and lymph node metastasis in breast cancer (PMID: 25888649) and overexpression has been reported in lung adenocarcinoma (PMID: 32154654). | ||||||||||
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