PRDM2: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

PRDM2

Synonyms

HUMHOXY1 | KMT8 | KMT8A | MTB-ZF | RIZ | RIZ1 | RIZ2

Gene Description

PRDM2, PR/SET domain 2, is a PR domain zinc finger protein and histone methyltransferase that encodes two proteins Riz1 and Riz2 (PMID: 27983647, PMID: 29883756). PRDM2 lies in a region of chromosome 1p that is often deleted in tumors and therefore, Prdm2/Riz may function as a tumor suppressor in various tumor types, including testicular germ cell tumors (PMID: 21369371; PMID: 20159667; PMID: 18712668; PMID: 27983647) and somatotroph adenoma (PMID: 32044406).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
7799	1	1p36.21	NM_012231	Tumor suppressor (PMID: 30606230)

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Gene Variants 2
Category Variants 1
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PRDM2 - Gene Detail

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