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Gene Symbol PRDM2
Synonyms HUMHOXY1 | KMT8 | KMT8A | MTB-ZF | RIZ | RIZ1 | RIZ2
Gene Description PRDM2, PR/SET domain 2, is a PR domain zinc finger protein and histone methyltransferase that encodes two proteins Riz1 and Riz2 (PMID: 27983647, PMID: 29883756). PRDM2 lies in a region of chromosome 1p that is often deleted in tumors and therefore, Prdm2/Riz may function as a tumor suppressor in various tumor types, including testicular germ cell tumors (PMID: 21369371; PMID: 20159667; PMID: 18712668; PMID: 27983647) and somatotroph adenoma (PMID: 32044406).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
7799 1 1p36.21 NM_012231 Tumor suppressor (PMID: 30606230)
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