MAPKAP1: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

MAPKAP1

Synonyms

JC310 | MIP1 | SIN1 | SIN1b | SIN1g

Gene Description

MAPKAP1, MAPK associated protein 1, is an mTORC2 complex subunit that acts as a scaffold and functions in substrate recognition (PMID: 37877351) and is involved in regulation of Akt signaling (PMID: 17043309) and cell survival (PMID: 16962653). MAPKAP1 mutations have been identified in ovarian cancer and skin cancer (PMID: 24161930) and overexpression has been identified in a variety of tumor types (PMID: 37877351) including breast cancer (PMID: 27780891), hepatocellular carcinoma (PMID: 23564492), and prostate cancer (PMID: 32088212).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
79109	9	9q33.3	NM_001006617	Unknown

Additional content available in

CKB BOOST

Gene Variants 3
Category Variants 1
Molecular Profiles 3
Evidence 0
Clinical Trials 0

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MAPKAP1 - Gene Detail

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