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Gene Symbol DEK
Synonyms D6S231E
Gene Description DEK, DEK proto-oncogene, is a nuclear chromatin binding protein (PMID: 30412857) that plays a role in DNA repair, hematopoiesis, chromatin remodeling, gene transcription, and apoptosis (PMID: 30854097). DEK-NUP214 fusions have been observed in pediatric myeloid leukemia (PMID: 24441146) and Dek overexpression in pancreatic cancer has been correlated with poor prognosis (PMID: 30854097) and overexpression has been observed in ovarian cancer (PMID: 30412857), TNBC (PMID: 29228721), and lung cancer (PMID: 29844811).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
7913 6 6p22.3 NM_003472 Oncogene (PMID: 30606230)
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