CD276: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

CD276

Synonyms

4Ig-B7-H3 | B7-H3 | B7H3 | B7RP-2

Gene Description

CD276, CD276 molecule, is also known ad B7-H3 and is a member of the B7 family of immune checkpoint regulators (PMID: 30035102) and may be a co-inhibitory protein for T-cell activation by binding to the IL20RA receptor (PMID: 31308249). Overexpression of CD276 (B7-H3) has been observed to correlate with poor prognosis, cell migration, and cell invasion in many solid tumor types including, endometrial, cervical, breast, kidney, colorectal (PMID: 30035102), non-small cell lung cancer (PMID: 31737785), and meningioma (PMID: 31629137).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
80381	15	15q24.1	NM_001024736	Unknown

Additional content available in

CKB BOOST

Gene Variants 2
Category Variants 0
Molecular Profiles 3
Evidence 35
Clinical Trials 9

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Gene Variants

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Global Drug Approvals

Drug Classes

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Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

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CD276 - Gene Detail

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