Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol ZRSR2
Synonyms OFD21 | U2AF1-RS2 | U2AF1L2 | U2AF1RS2 | URP | ZC3H22
Gene Description ZRSR2, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2, is a component of the splicesome that functions in 3' splice site recognition, therefore regulates expression of E2F transcription factors and genes in the Mapk/Erk pathways (PMID: 21041408, PMID: 25586593). ZRSR2 mutations are associated with myelodysplastic syndromes and acute myeloid leukemia, particularly in males (PMID: 21909114, PMID: 26769228).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
8233 X Xp22.2 NM_005089 Tumor suppressor (PMID: 30606230)
Additional content available in CKB BOOST