Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol PICALM
Synonyms CALM | CLTH | LAP
Gene Description PICALM, phosphatidylinositol binding clathrin assembly protein, encodes an adaptor protein that binds to clathrin, thereby playing a role in clathrin-mediated endocytosis and the regulation of protein internalization and localization at the cellular surface, including transferrin (PMID: 12832620, PMID: 22952941, PMID: 10436022). A fusion with PICALM and MLLT10 has been reported in T-cell acute lymphoblastic leukemia and acute myeloid leukemia (PMID: 23670296, PMID: 22871473), and somatic mutations in PICALM have been identified in follicular thyroid cancer (PMID: 27283500).
Additional content available in CKB BOOST