AXIN1: Gene Detail - Cancer Knowledgebase (CKB)

We’re improving your experience!

Starting April 21, you’ll be asked to log in or sign up for a free account after viewing 10 content pages each month.

Don’t worry—creating an account is quick and easy, and it comes with added benefits! Once logged in, you’ll not only continue accessing the content you already enjoy, but you’ll also unlock exclusive features like interactive donut plots for variant protein effects and variant impacts across the gene.

Stay tuned for these updates, and thank you for being part of our community!

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol

AXIN1

Synonyms

AXIN | CMDOH | PPP1R49

Gene Description

AXIN1, axin 1, axis inhibition protein 1 is a scaffold protein that regulates the Wnt signaling pathway and also Tp53, Myc, Tgfbeta, and Jun pathways (PMID: 30166345). Germline variations in AXIN1 have been associated with ovarian (PMID: 30929455), bladder (PMID: 31143301), kidney (PMID: 29053018), and colorectal cancers (PMID: 25236910) and loss of Axin1 function leads to increased cellular beta-catenin (CTNNB1), potentially promoting cell proliferation (PMID: 10700176).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
8312	16	16p13.3	NM_003502	Tumor suppressor (PMID: 30606230)

Additional content available in

CKB BOOST

Gene Variants 89
Category Variants 8
Molecular Profiles 91
Evidence 9
Clinical Trials 4

KEY FEATURES

CKB CORE^TM

CKB BOOST^TM

CKB FLEX^TM

Access 50 genes & related content

Access 2000+ genes & related content

Scalable & flexible content integration for 2000+ genes

Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

More about our plans

The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

CKB CORE allows for only a limited number of monthly page views for un-registered users. However, registration is free and allows for unlimited browsing of the CKB CORE content.

You have reached the monthly page view limit. For continued free access to CKB CORE, please register below:

We’re improving your experience!

AXIN1 - Gene Detail

Contact