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Gene Symbol BRIP1
Synonyms BACH1 | FANCJ | OF
Gene Description BRIP1, BRCA1 interacting protein C-terminal helicase 1, is involved in DNA repair and aids the tumor suppressor function of Brca1 (PMID: 14983014). BRIP1 germline mutations are associated with breast and ovarian cancers and somatic mutations are highest in endometrial, colon, and NSCLC (PMID: 27283171), while expression may promote breast cancer cell invasion (PMID: 32888398).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
83990 17 17q23.2 NM_032043 Tumor suppressor (PMID: 30606230)
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