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| Gene Symbol | CASP7 | ||||||||||
| Synonyms | CASP-7 | CMH-1 | ICE-LAP3 | LICE2 | MCH3 | ||||||||||
| Gene Description | CASP7, caspase 7, is an apoptosis-related cysteine peptidase that plays a central role in the execution-phase of cell apoptosis (PMID: 23979156). Germline variants in CASP7 have been observed to modify risk in cervical cancer (PMID: 25784056), gastric adenocarcinoma (PMID: 24040159), and childhood leukemia (PMID: 22548721), and a FGFR2-CASP7 fusion has been identified in breast cancer (PMID: 23558953). | ||||||||||
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