ARID5B: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

ARID5B

Synonyms

DESRT | MRF-2 | MRF2

Gene Description

ARID5B, AT-rich interaction domain 5B, encodes a member of the ARID DNA-binding protein family, which plays a role in gene transcription by forming a complex with Phf2 to facilitate the demethylation of H3K9me2 (PMID: 21890642, PMID: 11959810, PMID: 21532585). ARID5B germline variants are associated with acute lymphoblastic leukemia (PMID: 25310577, PMID: 24564228), and reduced expression has been identified in B-cell and T-cell acute lymphoblastic leukemia (PMID: 30420689).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
84159	10	10q21.2	NM_032199	Unknown

Additional content available in

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Gene Variants 10
Category Variants 1
Molecular Profiles 10
Evidence 0
Clinical Trials 0

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ARID5B - Gene Detail

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