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| Gene Symbol | CASP10 | ||||||||||
| Synonyms | ALPS2 | FLICE-2 | FLICE2 | MCH4 | ||||||||||
| Gene Description | CASP10, caspase 10, is an initiator caspase primarily involved in apoptotic signaling as it is recruited to the death-inducing signaling complex, binds to FADD, and subsequently activates downstream effector caspases, which then execute the apoptotic process (PMID: 12884866, PMID: 11583996, PMID: 10412980, PMID: 11717445), and appears to be involved in the regulation of inflammatory cell death (PMID: 36323068, PMID: 16585540). CASP10 mutations have been identified in gastric cancer (PMID: 11973654) and non-Hodgkin lymphoma (PMID: 12010812). | ||||||||||
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