Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene Symbol | AKT1S1 | ||||||||||
| Synonyms | Lobe | PRAS40 | ||||||||||
| Gene Description | AKT1S1, AKT1 substrate 1, encodes a protein that negatively regulates mTOR activity (PMID: 17510057, PMID: 17386266), and plays a role in the regulation of insulin sensitivity (PMID: 17277771, PMID: 27086010) and programmed cell death (PMID: 27086010). AKT1S1 mutations have been identified in breast cancer (PMID: 33685991), and elevated Akt1s1 expression has been identified in hepatocellular carcinoma (PMID: 31901857). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
