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Gene Symbol | RAD54L | ||||||||||
Synonyms | hHR54 | HR54 | hRAD54 | RAD54A | ||||||||||
Gene Description | RAD54L, RAD54-like, is a member of the SWI2/SNF2 family of dsDNA-dependent ATPases, which functions in homologous recombination in DNA repair (PMID: 20089461, PMID: 21704205). Overexpression of Rad54l has been demonstrated in non-small cell lung cancer (PMID: 21412013). | ||||||||||
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Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
RAD54L amp | no effect | |
RAD54L del | loss of function | Olaparib |
RAD54L E297* | loss of function - predicted | Olaparib |
RAD54L E436* | loss of function - predicted | Olaparib |
RAD54L F82S | loss of function - predicted | Olaparib |
RAD54L H110A | unknown | |
RAD54L inact mut | loss of function | Olaparib |
RAD54L K189A | loss of function | Olaparib |
RAD54L K189R | loss of function | Olaparib |
RAD54L L109Q | unknown | |
RAD54L L381Cfs*8 | loss of function - predicted | Olaparib |
RAD54L loss | loss of function | Olaparib |
RAD54L mutant | unknown | |
RAD54L over exp | no effect | |
RAD54L P112A | unknown | |
RAD54L P694L | unknown | |
RAD54L P85A | loss of function - predicted | Olaparib |
RAD54L Q90* | loss of function - predicted | Olaparib |
RAD54L R75* | loss of function - predicted | Olaparib |
RAD54L S49E | loss of function | Olaparib |
RAD54L Y309* | loss of function - predicted | Olaparib |