Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol NSMAF
Synonyms FAN | GRAMD5
Gene Description NSMAF, neutral sphingomyelinase activation associated factor, encodes an adaptor protein that is a member of the WD-repeat family of proteins that forms a complex with RACK1 and the p55 TNF receptor to modulate TNF-induced activation of neutral sphingomyelinase and the production of ceramide (PMID: 12391233, PMID: 8808629) and has roles in the regulation of apoptosis, cytoskeleton remodeling, and inflammation (PMID: 20534702, PMID: 29621545, PMID: 17599063). A fusion of AKT2 and NSMAF has been identified in pancreatic adenocarcinoma (PMID: 29617662).
Additional content available in CKB BOOST