HAVCR2: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

HAVCR2

Synonyms

CD366 | HAVcr-2 | KIM-3 | SPTCL | Tim-3 | TIM3 | TIMD-3 | TIMD3

Gene Description

HAVCR2, hepatitis A virus cellular receptor 2, encodes an inhibitory immune checkpoint receptor that is expressed on immune cells including CD8 and CD4-positive T-cells, regulatory T-cells, dendritic cells, macrophages, and natural killer cells (PMID: 31676858) and plays a role in the regulation of adaptive and innate immune responses (PMID: 18006747, PMID: 28258697, PMID: 27192565). Increased HAVCR2 expression has been identified in gastric cancer (PMID: 26464703), and tumor infiltrating lymphocytes in non-small cell lung cancer (PMID: 22363469), hepatocellular carcinoma (PMID: 22505239), and melanoma (PMID: 20819923), and is a target for immunotherapy (PMID: 30410357).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
84868	5	5q33.3	NM_032782	Unknown

Additional content available in

CKB BOOST

Gene Variants 1
Category Variants 0
Molecular Profiles 1
Evidence 0
Clinical Trials 0

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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HAVCR2 - Gene Detail

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